(This was a question I recently encountered on Quora. The answer below was written by Lucas Lundstrom, a Quora user, and I found it a very insightful read.)
This, in fact, has been tested large scale.
Japan is in dire national crisis because of this.
The issue is a bit complex, but can be summarized as that the Japanese men gave up on women because it was simply not worth it any more. They were expected to make the first move, pay for things even when the woman earned a good living, be the active part in love making, work double jobs and hardly be home just to meet expectations, give grandiose gifts at many, many days similar to Valentines day around the year, and so on. The women had grown away from the old ways of being considerate, supportive, warm, and kind and were now instead generally much more cold, distant, career driven, demanding, and selfish - but still held up all the demands on men which men had previously filled as a balance. Not 'I scratch your back - you taunt me for not making as much as my brother'.
They found that they could just put their foot down and say no. No more. Sex could be replaced through masturbation with VR and other tools and an advanced pornographic culture, or prostitution. Deep personal conversations, blowing off steam about your manager or best friend could be had through special business who cater to specifically this with trained hostess staff who have regulars. Having your head on someone's lap while watching a movie - also available. Etc., etc. The Japanese culture turned out to be very good at figuring out what little details in a relationship is actually important to us on a deep level, like having someone hold your hand while you are doing thisor listening to you explain how you feel about that, and then making a business of exactly that little niche.
So it happened. The Japanese men at a quite extreme and alarming rate started saying no to marriage. No to girlfriends. No to girls. They did not go into situational homosexuality as a cultural prison sexuality either, at least not in any major scale. Instead they found that with all that free time and available money to spend on anything that made themhappy they could have the worlds most extreme entertainment culture at the tip of their fingers. Games galore! Interactive movies, perverse comics, cool neo-sports, and so on.
So. How did the women react? Did they say "Oh, shit. We done fucked up now… Let's show the men that we are worth it. That we are actually really nice and warm too even if we are more independent than before. That we are loving and kind." No. They started using the term "Sōshoku(-kei) danshi", herbivore or grass-eating men, to condescendingly refer to those who reject the pleasure of the female flesh. They started large scale mocking all these men who refuse them. Claiming that they are not real men , that they are gentle, mild, sissy, closet gay, small boys, etc. This, er, did not get the men to come back. It made other men who saw how the women in large scale culture acted join the herbivores. And now it just spins like this, with the women pushing away the men further instead of chasing after the men.
As of now more than 60% of all men in their 20s are Sōshoku danshi. Here is the wiki for the phenomenon: Herbivore men - Wikipedia