Here is the Louis CK stand up that the advice is from:

http://youtu.be/q2F_LgV8YZo?t=2m25s

And here is Dan Savage taking it seriously:

http://www.avclub.com/article/february-12-2014-201115

I’m a 24-year-old straight male and I’m unattractive. Physically I’m not bad (not hot, but not ugly), but sadly, I’ve suffered from extreme depression all my life. I’ve gotten help, and it’s made me a little better, to the point where I’m functional. Now here’s my issue: Low self-esteem and lethargy aren’t exactly the best things for attracting the opposite sex. My sex life is poor, and my love life is nonexistent. I’ve never felt romantic chemistry with a woman ever, and I’m honestly losing any faith that it will ever happen. I’ve always tried to respect women, but my inability to attract them sometimes leaves me feeling resentful. I don’t want to become a bitter men’s-rights activist, so I’m wondering if you have any advice. Unattractive Guy Longingly Yearns

Dan Savage responds:

Did you see Louis C.K.’s most recent comedy special? He does this bit about schlumpy guys—guys like him—who don’t have much luck with women when they’re young. “I like getting older,” he says, “because for me, the kind of guy I am, getting older makes my life better. My sex life? Way better at 45… I’d like to make one of those ‘It Gets Better’ ads for dumpy young guys. We could use a little help, a little encouragement.”

Louis C.K.’s advice for you: “Stay relatively employed and washed; you’re going to be amazing in your 40s. You’re going to be the branch that she can grab before she hits the ground. It’s going to be so great. It just takes time for her circumstances to match your looks. When real shit matters, you’re going to be the sexiest motherfucker in the world.”

My advice for you: Keep working on your depression, throw yourself into nonsexual pursuits that you enjoy, find a job you like and build a career, locate and patronize (and overtip) an independent sex worker (which can help you learn to interact with women), and don’t allow bitterness to ruin you for all those women you’re gonna get with in your 40s.

I don't think a 24 year old guy can wait 16 years for the leftovers. That's a horrifying life to look forward to. It's more likely he is going to kill himself from your advice, Mr. Savage.