Extending Youth via Weight Loss Drugs

Attention is a bigger motivator than extending sexual vitality, even post-menopause.

Readership: All
Theme: Cracking Nuts; P0rn and Wh0redom is the Norm;
Length: 3,400 words
Reading Time: 18 minutes

Intro

In contrast to the last post, popular drugs have changed over the past 60 years.  Instead of having fun via an immediate dopamine hit, people are pursuing a dopamine-fueled hedonistic lifestyle by using drugs to adjust their body chemistry and physique to that end.

Readers have probably already heard about Ozempic and similar weight-loss drugs. They’re very popular in Taiwan. My wife estimates that about 30% of all her coworkers have taken Mounjaro to lose anywhere from 5 to 20 kg within 3-5 weeks.* I know these people. Their bodies look 10 years younger, their faces 10 years older.

In this essay, I’ll summarize this class of drugs and why it is in high demand, examine an article appearing in the New York Post on this topic, and offer some conclusions.

* A healthy rate of weight loss is about 1 kg./week. 4 kg./week is drastic and severe.

Why are Weight-Loss Drugs Popular?

The simple answer is that it’s not easy to lose weight.

As I’ve pointed out before, a strict diet and regular exercise are not enough to lose weight.  You MUST decrease calorie intake BELOW your daily metabolic rate, and do this consistently for MONTHS!

The main difficulty in losing weight is that most people cannot tolerate being hungry, even for an hour.  As soon as hunger pangs strike, they’ll reach for a sugary soft drink and a bag of Doritos.  They certainly cannot tolerate being hungry for MONTHS, which is what is necessary to lose weight.  Not only is it difficult to endure the constant hunger pangs, but it is also taxing on one’s concentration, mental faculties, psychological state, and self-discipline, which then affects one’s capitulation to the cravings.

Another difficulty is that as one ages, people tend to be less active, hormones change, and metabolic activity decreases, and as a result, the body tends to pack on the pounds more easily.  Stress (cortisol) tends to amplify this effect for many people.

A third snafu in losing weight is that it is practically impossible as long as one is consuming alcoholic beverages on any regular basis.  Alcohol reduces one’s inhibition and thus reduces one’s ability to resist bingeing on carbs and junk food. And besides, alcohol contains a LOT of calories (see breakdown below).

• A standard 1.5 oz. shot of liquor contains about 100-120 calories.
• A 5 oz. glass of wine has 110-160 calories.
• A 12 oz. pint of beer has 150-250 calories.

So, if you are older, have little to no self-discipline, and you want to continue a more or less sedentary lifestyle and have a drink now and then (all of which describes most people), drugs are not only the easiest recourse, but are almost absolutely necessary for losing weight.  Anything is considered better than utilizing brute willpower to endure hunger.

Enter GLP-1 Weight Loss Drugs, e.g. Ozempic, introduced in late 2023.

A Survey of GLP-1 Weight Loss Drugs

The New York Post article doesn’t offer much transferable information about this new class of weight-loss drugs, so for the readers’ benefit, I did a little research on it.  Here’s what I found.

GLP-1 Drugs

GLP-1 receptor agonists are designed to regulate Type 2 Diabetes and weight loss management.  These drugs work by mimicking hormones released by the gut after eating, increasing insulin release, and reducing appetite.

GLP-1s are FDA-approved (if that counts for anything), and are generally considered lifelong medications, both for diabetes and weight loss, as many users regain weight after stopping.

Listed in order of popular use.

Active Ingredient: Semaglutide
Brand Names: Ozempic*, Wegovy**, Rybelsus***

Active Ingredient: Tirzepatide
Brand Names: Mounjaro*, Zepbound**

Active Ingredient: Liraglutide
Brand Names: Victoza, Saxenda

Active Ingredient: Dulaglutide
Brand Names: Trulicity

Most of these drugs are once-a-week injections (Mounjaro*, Ozempic*, Trulicity, Wegovy**), while Liraglutide and Rybelsus*** are daily.

Future Trends: Newer drugs in development, such as Orforglipron (oral) and Retatrutide, are expected to provide further options.

Side Effects: Common side effects include diarrhea, nausea, vomiting, and, of course, decreased appetite.  Sexual side effects can include decreased desire, erection difficulties, and vaginal dryness, typically related to the body’s natural response to calorie restriction.

* Predominantly used for regulating Type 2 Diabetes.
** Predominantly used for chronic weight loss management.
*** Rybelsus is the only oral (pill) GLP-1 receptor agonist currently FDA approved.

How GLP-1 Drugs Can Affect Libido

GLP-1 drugs trigger rapid weight loss, causing fatigue and/or changing hormones, either of which dampens brain reward signals and can decrease libido.  However, some users experience a higher libido due to better metabolic health, improved self-image, and increased confidence.

The Key Impacts of GLP-1 drugs on Libido are as follows.

• Positive Physical Factors: Once a person loses a lot of weight, animated activity and exercise feel good again.  Clothes fit.  They can look in the mirror and feel confident about themselves instead of self-loathing.  They are much more attractive and receive more positive attention, which is encouraging, motivating, and satisfying.  That visual dopamine hit, coupled with decreased cortisol, can kick libido into overdrive for some people.
• Improved Self-Esteem: Many users report increased libido due to improved self-image, body confidence, and improved vascular health.
• Negative Physical Factors: Rapid weight loss due to sub-metabolic calorie intake can cause severe fatigue, shifting body chemistry into conservation and away from reproductive-related interests.
• Reduced Reward Seeking: GLP-1 agonists act on the brain to decrease appetite and hunger cravings, which may simultaneously reduce dopamine-driven reward signals for pleasure, including sexual desire.
• Sexual Dysfunction: Some studies report an increase in sexual disinterest, such as erectile dysfunction in men or difficulty reaching orgasm in both genders, similar to effects seen with other metabolic changes, restricted calorie consumption, and rapid weight loss.

Moreover, studies have had mixed results and do not offer any uniform conclusions.  Although most all GLP-1 users report a flagging libido, some reports note that the libido-reducing effects can settle over time as the body adjusts, or that the net effect is positive for many users due to a more active lifestyle and improved health.  Some report more sexual desire after weight loss.

There is, as of now, a paucity of high-quality studies specifically designed to examine how GLP-1s affect libido.  Much of what is currently known comes from clinical experience rather than formal research data.  IOW, GLP-1 users are guinea pigs in this respect.

I am inclined to believe that fasting without the aid of weight-loss drugs has a less deleterious effect on libido.

The New York Post Article

New York Post: We lost weight on GLP-1 drugs — and then we lost our sex drives (2026/2/26)

Summary: People say weight loss drugs like Semaglutide (Ozempic) and Tirzepatide (Mounjaro) have helped them lose weight — but it has also tanked their libidos.  3 case studies are offered.

The most obvious problem with the content of this article is that all the subjects are post-Wall or perimenopausal women.  But after I studied this article, I thought… maybe that is the whole point — giving post-Wall Cougars a few more years to prowl the SMP, hence the title of this post, Extending Youth via Weight Loss Drugs.  More on this in the Conclusions.

Another issue is the readability. The article is written to simulate a journey of discovery about how to lose weight via weight loss drugs while retaining sex drive — appealing to typical fleshly desires.  As such, the article is written in a stream of consciousness style, and the information and the case subjects themselves are hard to track.

A third issue is that (I believe) the article is a subtle advertisement of weight loss drugs and other products and treatments, targeting mid-life individuals (who are probably the largest consumer group) who have heard about these drugs but are still sitting on the fence.  Beware of Big Pharma!

In the case studies below, I have provided some relevant information and reorganized the content of the NYP article to help us analyze the issue more objectively.  [Emphasis mine.]

Case Study 1: Christine Smith-Reed

Age:  50
Status: Married for 17 years (since age 33)
Note: Menopausal

“Christine Smith-Reed had tried it all: a dietitian, grueling workouts, even weight-loss surgery in Mexico. Yet the pounds kept creeping up, and her body was becoming insulin resistant.

So at 50, the salon owner from Columbia City, Oregon, turned to Tirzepatide, the active ingredient in GLP-1 drugs like Mounjaro and Zepbound, hoping to rein in her blood sugar and finally stabilize the scale.

Ultimately, she got the body she wanted — but weight wasn’t the only thing she lost.

“All of a sudden, I couldn’t care less about sex”, Smith-Reed told The Post.

Smith-Reed’s sex life with her husband had ups and downs over their 17-year marriage — not uncommon for a long-term relationship. Usually, she was the one keeping things spicy — but after starting a GLP-1, her libido tanked.

“I would participate, but I definitely wouldn’t climax, or if I did, it took a lot of effort.  And I feel guilty for that because it isn’t due to poor performance on my husband’s part”, she said.  “It’s literally that something is wrong with me.”

Oh, my!  She had to do ¡Work! to make herself cum!  That’s NOT ‘Fun’.  Oh Noes!

“The problem went beyond the bedroom.

“When you go from having a very active sex life to having a nonexistent sex life, there was a lot of silence”, Smith-Reed said.  “There were cold shoulders.  There were hurt feelings — probably from both of us.”

So without regular diddling, her relationship dried up to nothing.  I think that’s pretty typical within our Sex-Centric culture, unfortunately.

“For Smith-Reed, relief came in the form of a synthetic peptide known as PT141, also called Bremelanotide. It stimulates the central nervous system, targeting the brain’s melanocortin receptors to activate sexual desire and arousal.

The FDA approved Bremelanotide in 2019 to treat hypoactive sexual desire disorder in premenopausal women, though it’s sometimes used off-label for men experiencing erectile dysfunction.

After she gave herself the first shot, Reed-Smith’s libido flickered back to life.

“It’s not like [my sex drive] went into overdrive, but I had no problem achieving orgasm.  And that happened more than once”, she said.  “It was like coming up for air when you’ve been drowning.  Like I’m not broken.”

Thank God!  Her orgasms are ‘Fun’ again!  Whew!  We almost had another bitter Karen!

“Smith-Reed, however, has no plans to quit [taking Tirzepatide].

“I would rather be in this [thinner] body than be sexually active”, she said.  “What does that say about me?  I don’t know.”

I know.  See my Conclusions below.

“Even so, she hopes other women facing similar challenges don’t turn that frustration inward.

“I want every woman to know that they aren’t broken. It’s because a medication has a side effect, and like any other side effect, it doesn’t affect everyone”, Smith-Reed said.  “But if it does, understand that you have not lost something.  There are ways you can come back from it.”

In her view, women who can’t cum easily and often at the mere urgent stroke of an erectile glans are ‘broken’, and GLP-1 drugs can ‘break’ fatties (in this view).  Oooh!

Lest we forget, the Manosphere has a vastly different and more practical concept of what makes a woman ‘broken’.

Case Study 2: C. J. Rock

Age: 47
Status: Engaged
Note: Perimenopausal

C. J. Rock compared her experience with weight loss before and after taking GLP-1 drugs.

“In the past, if I had lost weight, I got a self-esteem boost, which is almost like dopamine.  It makes you crave sex more”, the 47-year-old explained. But when she started taking Tirzepatide, her libido dropped.”

Oh Noes!

“She lost 70 pounds in seven months and was feeling good in her skin.  But when her fiancé tried the moves that used to turn her on, her body didn’t respond.

“My sex drive was normal [before taking the drug].  Two or three times a week, I had the craving and the desire”, she said — but then [after taking Tirzepatide], suddenly, it was gone.

“I was almost numb to [sexual stimulation]”, she said.  “There would be nights where I’d wonder what was wrong with me.”

Again, we see this sex-centric value paradigm. She thinks she’s ‘broken’ if she can’t get turned on and get off.

“For Rock, the answer was patience.  “Once I’d been on the drug for a while, my sex drive did come back, but I wouldn’t say it’s super strong”, she said.  “I think my body just kind of got used to the drug and adjusted eventually.”

But for Rock, one thing was clear: “[GLP-1 drugs] do work.”

“For years and years and years I lived in a world where it was always ‘someday,’ ‘I’ll do it when…,’ but now that’s today”, she said.  “It gave me my life back.”

Question: What exactly gave her her ‘life’ back?  Was it becoming thin and attractive again, and thus being able to draw Attention, or was it being able to bust her backside in the bedroom with her significant other?  Male readers will be disappointed with the answer (given in the Conclusions).

Case Study 3: Nathalia Souza

Age: 37
Status: Married
Note 1: Post-Wall, pre-menopausal
Note 2: Souza’s case illustrates that the changes in libido aren’t limited to women navigating menopause.

“Nathalia Souza, a 37-year-old from New Jersey, started taking Tirzepatide after three years of dieting and exercising resulted in just 30 pounds of weight loss.

In the seven months since starting the medication, Souza has dropped another 22 pounds — and overall, she calls the experience a success.  But there was one unexpected downside.

“I had a very high sex drive, and probably two months in, I noticed I had no desire anymore”, Souza said.”

OMG!  NOT Again!  Will GLP-1 create another sexually frustrated Karen?

“The change was stark.  Before the drug, she and her husband were having sex four or five times a week.

“Five months in, I didn’t even want my husband to come near me”, Souza said.  “Like ‘No, stop, I don’t even want to kiss you.’”

Well, perhaps he came somewhere else.

“The abrupt shift in Souza’s sex drive left her shaken, making her question whether the weight-loss drug was worth it.

“It kind of numbs you”, she said.  “I want to feel normal again.”

Once again, she thinks she’s ‘broken’ if she can’t get whacked off. Sex is the be-all, end game of their whole lives. It would be different if these broads viewed satisfying sex as an indicator of a healthy marital relationship, but no, for them, it’s all about getting off.

However… Souza has a rare sense of responsibility to her husband (or rather, to her source of emotional and financial security).

“This is where I draw the line”, she said.  “I’m not losing my marriage over this.”

Before giving up on the meds, she stocked up on supplements — vitamin D, magnesium, creatine, and maca root — but nothing worked.

Then she discovered URO Vaginal Moisture & Mood, a daily supplement formulated to support natural lubrication, mood, stress relief, and arousal.  Within a few weeks, Souza started feeling a change.

Souza plans to discontinue Tirzepatide once she reaches her goal weight and try to maintain it on her own.”

Whew!  Another Karen formation is narrowly avoided, thanks to drugs that counteracted the side effects of other drugs.  We live in a drugged-up nation.

Jack’s Conclusions

From the NYP article, in total, we see 3 middle-aged women drugging themselves up in a lazy effort to be as thin, attractive, and horny as possible, essentially extending their youth via weight loss drugs and other medications to fine-tune the results.

All 3 women in the case studies took Tirzepatide and experienced a reduced libido.  That’s not a good report on Tirzepatide.  So if you or your bedmate are looking to conduct a guinea pig experiment on yourself with GLP-1 drugs, try something else.

Perimenopause is known to reduce estrogen and testosterone in women, and thus, their libidinous desire.  However, the two menopausal case studies above, Reed-Smith and Rock, seem to be much hornier than most other women their age, defying this eventuality.  Or maybe they’re simply looking to extend the joyous jiggles for as long as possible.  Nevertheless, making the transition from having a very high sex drive to no desire at all after taking GLP-1 drugs was an unexpected snafu in their sex lives that was more than they could accept.

The article mentioned that their menopause transition posed a significant challenge to Reed-Smith and C. J. Rock, who had to untangle the overlapping effects of aging, hormones, menopause, and GLP-1 drugs on their libido by adding a witches’ brew of medications to counteract the libido-killing effects of Tirzepatide. They lamented that Big Pharma $ucking doctors focus on weight loss and didn’t give much attention to the side effect of losing equally important libido, nor did they offer much advice about how to deal with the flagging sex drive.  As Rock said, “It’s just so confusing, like picking your poison.”

Somebody needs to tell them that doctors make money off of selling them drugs, and are less motivated to help them heave hoe.

The way the article is written, as well as a few others I’ve seen on this topic, makes me believe the current GLP-1 craze is NOT “just” about losing weight in the interest of maintaining physical fitness and good health as one ages past menopause, but specifically for losing weight to stay sexually desirable and also sexually functional in the SMP, and for as long as one is able to, and as much as one can as one ages.  And why all the trouble?  Ultimately, it’s NOT “just” to enhance one’s sexual attractiveness either, but to enhance one’s sexual attractiveness such that women can continue to attract Attention as well as the most sexually attractive bedmates that their aging, infertile, sagging, wrinkled body can attract, and/or to sustain the ‘romance’ and randy orgasms of youth for a few more years. From these case studies, I am led to believe there exists an idol / god of female Tingle tantrums and mind-blowing orgasms, as this would definitely explain the priorities demonstrated here.

Weighty wives might also want to lose weight to demonstrate their love for God (as if… heh) by loving their bodies, and also to keep their bored hubbies interested, but because men’s interests are moot, this was not mentioned in the NYP article.

There is one caveat, and this is a conjecture based on my own observations, so YMMV.  Extremely libidinous women tend to stick with one man because they need regular servicing, and they can’t endure a sexual drought for any period of time.  So they choose surety over variety rather early in life, and/or they tend to stay with their relationships long-term.  All 3 case studies above appear to support this theory, although they all arrived at this conclusion belatedly (due to feminism’s emphasis on postponing marriage).

However, Christine Smith-Reed and C. J. Rock both made statements to the effect that they would rather be thin and attractive than to have a satisfying sex life.  That says mountains about how important Attention is to women, even post-menopause.  Only Souza, relatively younger, married, and horny as həll (needing to get rammed 4-5 times a week at age 37!!!), was more concerned about the effects on her marriage.  I was surprised about this, because before I read this article, I believed that most “girls just wanna have fun”, i.e., get off on sex AMAP, no matter what their SMV.  But here we find that, for these women at least, Attention and the sense of security that comes of having options, trump regular d!ck!ng and Bedroom Fun (but not by much).

Finally, we know that sex is central to a good marital relationship, but for some people, libido is about all they’ve got to hold their relationship together.  When sex drive goes south during endocrinal winters, the whole relationship sinks.  This appears to be the case for Smith-Reed and Souza.  C. J. Rock didn’t seem to care too much, one way or the other, which is even worse, IMO.

Related

• Σ Frame: Fasting (2010/3/4)
• Σ Frame: Less Weight, Better Health! (2013/1/3)
• Σ Frame: Neuroscientist Explains What Fasting Does to Your Brain (2015/12/11)
• Σ Frame: 10 Ways to Increase Dopamine Levels without Medication — Collective Evolution (2018/1/19)
• Σ Frame: How to Transform Your Image (2020/8/12)
• Σ Frame: Obesity lowers Testosterone (2023/8/16)
• Jayèn Clinic: What is Ozempic Face (2025/2/12)
• Daily Mail: What Ozempic really does to your face: All the tell-tale signs of using skinny jabs, from bigger lips to sunken eyes (2025/6/27)
• Yahoo!: What is Ozempic Face? (2026/1/6)