I would just like advice on what somebody i am very close to could do in his situation to help his depression and get his life goals back on track

He is 39,married with a woman who is very uncooperative and who never truly liked him-Worse then he has a child with the women. He is financially stable but has to work many hours and ontop is the only of his siblings who lives with his parents that are very old and require alot of care.The wife does not want to live with him so he does not get the help he needs. his doctor diagnosed him with depression and i could tell that was the case from how he acted Please any help would be appreciated