The story is set right after the events of "Kamp Krusty." Santa's Little Helper follows the trail of Homer Simpson and Marge Simpson's clothes leading him to Bart Simpson's treehouse, where they were having sex. Chief Wiggum and Officer Lou arrive at the scene, having been called by Ned Flanders. Homer tells them the kids are fine, before showing them a postcard from Kamp Krusty. The scene switches to the camp, where everything is getting ruined by Bart and the other bullies.

The traumatized kids return on a bus, guided by Krusty the Clown. The kids are taken to therapy and the therapist says to Marge to keep an eye on Bart. Back at home, Bart fakes PTSD and interrupts Homer and Marge's sexual activity. The next day, Bart stays at home watching TV. With Bart on their bed and being unable to have fun with Marge, Homer goes to work early and finds out what happens when the Power Plant is empty.

Bart has a nightmare of the camp when they went on the canoe and asks Lisa for help. Homer gets more productive than ever and gets a raise by Mr. Burns while Bart and Lisa go to the amusement park where they cut the line thanks to the trauma they suffered from.

Homer refuses to have sex with Marge and she thinks they need the help of a therapist too who suggests taking the kids back to Kamp Krusty, which was transformed into an adult retreat called Klub Krusty. Bart and Lisa find a cabin they have visited after escaping with the canoe and remember another kid with them named Charlie who fell in the rapids and never come back up. Marge and Homer have some fun at the club while Bart and Lisa report Charlie missing to the club security which reveals he's alive, and also that Charlie is not a kid but a little person.

During the credits, shots of Homer Simpson clones are shown at work as a Barry White-like singer is heard singing in the background about not wanting to be intimate with the object of the song.

Keep in mind that homer becomes a more productive man when he refuses to have sex with marge. Which leads to homer getting a raise and becoming a much healthier and more intelligent man