Who is the most accomplished/important female in world history, and would she make the top 500 when compared to the most accomplished/important men in history?

I got to thinking about this because of the Elizabeth Holmes debacle. Many of the females historically propped up as groundbreaking / inspirational women ended up being failures/frauds. Elizabeth Holmes - massive fraud. Emelia Earhart - crash and burn. Hillary Clinton - most embarrassing political loss in world history.

I can't even come up with a name for who is #1 on their list. But whoever it is, they would be lucky to crack the top 500 resumes of the most important men in world history.