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Adaptive variation in testosterone levels in response to immune activation: Empirical and theoretical perspectives

UnHope20

September 5, 2021
6 upvotes
/r/Male_Studies
https://www.tandfonline.com/doi/abs/10.1080/19485565.2006.9989113?src=recsys
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Post Information
Title Adaptive variation in testosterone levels in response to immune activation: Empirical and theoretical perspectives
Author

UnHope20

Upvotes 6
Comments 10
Date September 5, 2021 11:31 PM UTC
(4 years ago)
Subreddit Posted in /r/Male_Studies
Original Link https://old.reddit.com/r/Male_Studies/comments/pinty3/adaptive_variation_in_testosterone_levels_in/
Archive Link https://theredarchive.com/r/Male_Studies/adaptive-variation-in-testosterone-levels-in.1216197
https://theredarchive.com/post/1216197
Red Pill terms in post
testosterone
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Comments

[–]UnHope20[S] 0 points1 point2 points 4 years ago (9 children) | Copy Link

High testosterone levels reflect investment in male reproductive effort through the ability to produce and maintain muscle tissue and thus augment mate attraction and competitive ability. 

However, high testosterone levels can also compromise survivorship by increasing risk of prostate cancer, production of oxygen radicals, risk of injury due to hormonally‐augmented behaviors such as aggression, violence and risk taking, reduced tissue and organ maintenance, negative energy balance from adipose tissue catabolism, and suppression of immune functions.

Here, I briefly discuss how inter‐ and intra‐individual variation in human male testosterone levels is likely an adaptive mechanism that facilitates the allocation of metabolic resources, particularly in response to injury, illness or otherwise immune activation. 

Maintaining low testosterone levels in resource‐limited and/or high pathogen‐risk environments may avoid some immunosuppression and suspend energetically‐expensive anabolic functions.

Augmenting testosterone levels in the presence of fertile and receptive mates, areas of high food resource availability, and low disease risk habitats will function to maximize lifetime reproductive success.

[–][deleted] 1 point2 points3 points 4 years ago (8 children) | Copy Link

It would be interesting to see if the researcher could break down further into whether it is high testosterone level or metabolites (estrogen & DHT) which are responsible for specific negative functions.

[–]UnHope20[S] 1 point2 points3 points 4 years ago (7 children) | Copy Link

Great question. It's fairly well documented that androgens suppress immune response. But I want to suggest that I wouldn't think of it as 'negative'. The immunosuppressive effect of androgens can be adaptive. I'd say that Immune response is just like everything else, at the right time it's awesome but at the wrong time... Not so much (Think allergic reactions).

For example, the robust immune response that females typically exhibit as a result of their significantly lower androgen levels is great for lower cancer risk and fighting off infections but is terrible for autoimmune diseases. Hence autoimmune diseases show a clear female bias while cancer show a clear male bias. See here for more details.

EDIT: Btw love the avatar.

[–][deleted] 1 point2 points3 points 4 years ago (6 children) | Copy Link

I agree concerning the androgens and immune suppression. I prefer to refer to it as regulation. I have psoriatic arthritis, and raising test, dhea, pregnenolone are key to controlling inflammation and encouraging repair (Vasquez).

[–]UnHope20[S] 1 point2 points3 points 4 years ago (5 children) | Copy Link

Sorry you have to deal with that. But thanks for sharing.

That's very fascinating. Are you on TRT of any kind?

[–][deleted] 1 point2 points3 points 4 years ago (4 children) | Copy Link

Vasquez is an endocrinologist with some articles out there dealing w the issue of inflammation and arthritis. Following his advice, I''ve been taking pregnenolone and DHEA to increase test and lower cortisol and SHBG; grape seed extract to lower conversion to estrogen.

I'm 60, and before starting this a few years ago, I was walking bent over like a 90 yo, bit I'much better now, and my joints, Achilles, and flare-ups (rib enthisitus) are no where near as painful as they were

[–]UnHope20[S] 1 point2 points3 points 4 years ago (3 children) | Copy Link

That is super cool! I'm glad to hear that you are doing better.

You've elevated my interest. I'll have to dig into the literature on this topic. Do you know Vasquez first name by any chance?

[–][deleted] 1 point2 points3 points 4 years ago (0 children) | Copy Link

I have a link to one of his articles. Give me some time to find it and I'll post it it here 😊

[–][deleted] 0 points1 point2 points 4 years ago (1 child) | Copy Link

Here we go... Alex Vasquez...

https://ndnr.com/endocrinology/orthoendocrinology-an-anti-inflammatory-approach-to-dysendocrinism/

This is a different article than the first I read in the American Journal of Rheumatology (?) about 5 years ago in my rheumy's office. It's funny, as I was so excited by the article I tried to discuss it w the rheumatologist, but he dismissed discussion as though it it's not valid unless the pharma rep brings it up. I even had to explain to him what pregnenolone is!!! How do you go through 10 years of schooling, special schooling and training in medicine, and not know what pregnenolone is?!?

[–]UnHope20[S] 1 point2 points3 points 4 years ago (0 children) | Copy Link

Thanks a ton!!!

Yeah I've found that for some reason, endocrinology seems to be the one area where a lot of doctors have a major blind spot.

I had an endocrine issue that made me sick for over a decade. Ended up going to a university.

Caused a fight between the medical team before they finally found the problem.

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