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Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality

UnHope20

October 7, 2022

12 upvotes

/r/Male_Studies

https://www.science.org/doi/10.1126/science.abn3100

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Title	Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality
Author	UnHope20
Upvotes	12
Comments	1
Date	October 7, 2022 12:53 AM UTC (3 years ago)
Subreddit	Posted in /r/Male_Studies
Original Link	https://old.reddit.com/r/Male_Studies/comments/xxlbfz/hematopoietic_loss_of_y_chromosome_leads_to/
Archive Link	https://theredarchive.com/r/Male_Studies/hematopoietic-loss-of-y-chromosome-leads-to.1215737 https://theredarchive.com/post/1215737

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[–]UnHope20[S] 2 points3 points4 points 3 years ago (0 children) | Copy Link

Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal and mechanistic relationships have yet to be established. Here, we show that male mice reconstituted with bone marrow cells lacking the Y chromosome display increased mortality and age-related profibrotic pathologies including reduced cardiac function.

Cardiac macrophages lacking the Y chromosome exhibited polarization toward a more fibrotic phenotype, and treatment with a transforming growth factor β1–neutralizing antibody ameliorated cardiac dysfunction in mLOY mice.

A prospective study revealed that mLOY in blood is associated with an increased risk for cardiovascular disease and heart failure–associated mortality. Together, these results indicate that hematopoietic mLOY causally contributes to fibrosis, cardiac dysfunction, and mortality in men