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Combined exposures to bisphenols, polychlorinated dioxins, paracetamol, and phthalates as drivers of deteriorating semen quality

UnHope20

June 21, 2022

5 upvotes

/r/Male_Studies

https://www.sciencedirect.com/science/article/pii/S0160412022002495#t0015

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Post Information

Title	Combined exposures to bisphenols, polychlorinated dioxins, paracetamol, and phthalates as drivers of deteriorating semen quality
Author	UnHope20
Upvotes	5
Comments	1
Date	June 21, 2022 11:16 PM UTC (4 years ago)
Subreddit	Posted in /r/Male_Studies
Original Link	https://old.reddit.com/r/Male_Studies/comments/vhqg3n/combined_exposures_to_bisphenols_polychlorinated/
Archive Link	https://theredarchive.com/r/Male_Studies/combined-exposures-to-bisphenols-polychlorinated.1215822 https://theredarchive.com/post/1215822

Comments

[–]UnHope20[S] 1 point2 points3 points 4 years ago (0 children) | Copy Link

Background Semen quality in men continues to decline in Western countries, but the contours of the issue remain obscure, in relation to contributing chemicals.

Objectives To obtain more clarity about the chemicals that drive the deterioration of semen quality, we conducted a mixture risk assessment based on European exposures.

Results Highly exposed subjects experienced combined exposures to the 9 chemicals that exceeded the index value of 1 by more than 100-fold; the median was a 17-fold exceedance. Accounting for median background exposures to the remaining 20 chemicals added a Hazard Index of 1.39. Bisphenol A made the largest contribution to the HI, followed by polychlorinated dioxins, bisphenols S and F and DEHP. Eliminating bisphenol A alone would still leave unacceptably high mixture risks. Paracetamol is also a driver of mixture risks among subjects using the drug.

Conclusions Tolerable exposures to substances associated with deteriorations of semen quality are exceeded by a large margin. Bisphenols, polychlorinated dioxins, phthalates and analgesics drive these risks. Dedicated efforts towards lowering exposures to these substances are necessary to mitigate risks.