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Negative Association between Testosterone Concentration and Inflammatory Markers in Young Men: A Nested Cross-Sectional Study

UnHope20

March 15, 2021

2 upvotes

/r/Male_Studies

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Post Information

Title	Negative Association between Testosterone Concentration and Inflammatory Markers in Young Men: A Nested Cross-Sectional Study
Author	UnHope20
Upvotes	2
Comments	1
Date	March 15, 2021 7:31 PM UTC (5 years ago)
Subreddit	Posted in /r/Male_Studies
Original Link	https://old.reddit.com/r/Male_Studies/comments/m5srsu/negative_association_between_testosterone/
Archive Link	https://theredarchive.com/r/Male_Studies/negative-association-between-testosterone.1216435 https://theredarchive.com/post/1216435

Comments

[–]UnHope20[S] 0 points1 point2 points 5 years ago (0 children) | Copy Link

Low grade systemic inflammation (LGSI) as well as androgen deficiency has in older men been associated with several pathologies, including cardiovascular disease (CVD). We wanted to investigate whether low testosterone levels are linked to biomarkers of LGSI already in young age, before any concurrent manifestations of CVD or other systemic diseases.

Among 21 inflammatory markers, macrophage inflammatory protein 1-alpha (MIP1a) (ß = −0.025; p = 0.028), 1-beta (MIP1B) (ß = −0.015; p = 0.049) and tumor necrosis factor alpha (TNFa) (ß = −0.015; p = 0.040) showed negative association to total testosterone (TT) levels. MIP1a (ß = −1.95; p = 0.001) and TNFa (ß = −0.95; p = 0.014) showed negative association to calculated free testosterone (cFT) levels.

Compared to men with normal TT and cFT levels, TNFa levels were higher in men with subnormal levels of TT (mean ratio 1.61; p = 0.006) and cFT (mean ratio 1.58; p = 0.007). Also, MIP1a levels were higher in men with subnormal levels of TT (mean ratio 1.84; p = 0.030).

Subnormal testosterone may already in young age associate to LGSI, which might be a part of the mechanism underlying adverse health outcomes of male hypogonadism.