Recently, one of the things I've heard a few girls I've been with say is "I'm so ugly" or "I have no talent -- I wish I had a talent like that" or "I'm so fat" or "I'm so (insert negative trait here)".

My current response is to ignore it, but often this leads to odd lulls in a conversation where it seems like I am confirming whatever their insecurities are. What is the general protocol for dealing with shit like this?