I thought this Cell paper might interest you guys:

Loss of chromosome Y in primary tumors00646-3)

Highlights

  • Somatic Y copy number variations are identified in >5,000 TCGA male tumors
  • LOY (Loss Of Y chromosome) is a frequent event, and frequency varies by tumor type
  • Evidence that LOY can be either a passenger or driver event in cancer
  • LOY is an early and clonal candidate driver in uveal melanoma

Abstract

Certain cancer types afflict female and male patients disproportionately. The reasons include differences in male/female physiology, effect of sex hormones, risk behavior, environmental exposures, and genetics of the sex chromosomes X and Y. Loss of Y (LOY) is common in peripheral blood cells in aging men, and this phenomenon is associated with several diseases. However, the frequency and role of LOY in tumors is little understood. Here, we present a comprehensive catalog of LOY in >5,000 primary tumors from male patients in the TCGA. We show that LOY rates vary by tumor type and provide evidence for LOY being either a passenger or driver event depending on context. LOY in uveal melanoma specifically is associated with age and survival and is an independent predictor of poor outcome. LOY creates common dependencies on DDX3X and EIF1AX in male cell lines, suggesting that LOY generates unique vulnerabilities that could be therapeutically exploited.

And this is an article about the same paper:

The Y chromosome is disappearing, and this fact is already causing problems for men

Excerpt

Long before any species-wide overhaul, countless men are already losing the Y chromosome cell by cell. Starting in their fifties, bone-marrow stem cells sometimes mis-segregate it during division.

The resulting white-blood-cell lineages, missing their Y, multiply quietly. By 80 years old, more than 40 percent of men carry sizable pockets of this “mosaic loss of Y” in their blood.

Tracking 1,153 Swedish men in their seventies and eighties, researchers found that those with the loss died 5.5 years earlier, suffered more solid tumors and heart disease, and faced a seven-fold rise in Alzheimer’s.