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Testosterone and depression: systematic review and meta-analysis

UnHope20

February 27, 2021

1 upvotes

/r/Male_Studies

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Post Information

Title	Testosterone and depression: systematic review and meta-analysis
Author	UnHope20
Upvotes	1
Comments	1
Date	February 27, 2021 6:03 AM UTC (5 years ago)
Subreddit	Posted in /r/Male_Studies
Original Link	https://old.reddit.com/r/Male_Studies/comments/lthqld/testosterone_and_depression_systematic_review_and/
Archive Link	https://theredarchive.com/r/Male_Studies/testosterone-and-depression-systematic-review-and.1216457 https://theredarchive.com/post/1216457

Comments

[–]UnHope20[S] 0 points1 point2 points 5 years ago (0 children) | Copy Link

Background: Studies suggest that testosterone (TT) replacement may have an antidepressant effect in depressed patients.

Objective: The objective of this study was to explore the effect of TT administration on depression using both a systematic review of the literature and a meta-analysis.

Results: Seven studies (N=364) were identified that included a placebo-control group in a double-blind design. Eligibility criteria were clearly reported in all trials. Meta-analysis of the data from these seven studies showed a significant positive effect of TT therapy on HAM-D response in depressed patients when compared with placebo (z=4.04, P<0.0001).

Subgroup analysis also showed a significant response in the subpopulations with hypogonadism (z=3.84, P=0.0001) and HIV/AIDS (z=3.33, P=0.0009) as well as in patients treated with TT gel (z=2.32, P=0.02).

Conclusions: TT may have an antidepressant effect in depressed patients, especially those with hypogonadism or HIV/AIDS and elderly subpopulations. The route by which TT is administered may play a role in treatment response.