What are some tactics you guys have used to defeat manipulative, sadistic, and Machiavellian people in social situations or in the career world?

I am sure it is a given that we will all run into these personalities at some point, the kind that are just miserable people hellbent on ruining others. Sometimes, especially if you are a high SMV male, you attract envy which in turn makes these people really go after you.

I've read the 48 laws of power so I rather that someone not refer to the book itself or recommend it, instead give personal experiences and actionable steps you have taken.