This might be more useful for those who can't talk to girls directly and rely mostly on situational openers to get started, but is actually a great way for curing meekness and overthinking trivial stuff in general, which is applicable in straight-up relationships too.

Scenario: You get on the bus. You sit down next to a hot girl. She pulls out her phone to check something, and you see that she's got a phone cover with the Green Lantern logo on it. A stray thought flashes through your head:

"Bet I can guess who your favorite member of the Justice League is."

But your mouth won't move. A thousand negative outcomes run through your head. She's already put away her phone, and is reading a book instead. Your window of opportunity for a great and comfortable opener has passed. As you contemplate and struggle to open your mouth to just say "Hi!", the bus stops and she gets off.

Another path for your life to take has closed. You wish you had spoken sooner.

But here's a way to stop your unwieldy mouth and over-analyzing brain from cock-blocking you - when you're in casual situations, just blurt out what's on your mind. The receptionist at the hospital has a lovely necklace - tell it to her. The old man down the road has a kick-ass Mercedes parked in his garage? Chat to him about it. Do not hold your thoughts back, no matter what. Because your mouth will learn to act faster than your brain - and instead of being stuck with a panicky brain and a sad penis, you will be blessed with an indifferent brain and a very happy penis.

And this will help you with everything - business, job interviews, dealing with relationships, dealing with teammates/coworkers, and dealing with professors.