Starting in the late teens, the parental age of both sexes positively correlates with de novo mutations in offspring, with paternal age providing a stronger correlation.

RSDevotion1 · 2023-02-22T02:51:05+00:00

The number of de novo mutations (DNMs) found in an offspring's genome increases with both paternal and maternal age. But does the rate of mutation accumulation in human gametes differ across families? Using sequencing data from 33 large, three-generation CEPH families, we observed significant variability in parental age effects on DNM counts across families, ranging from 0.19 to 3.24 DNMs per year. Additionally, we found that ~3% of DNMs originated following primordial germ cell specification in a parent, and differed from non-mosaic germline DNMs in their mutational spectra. We also discovered that nearly 10% of candidate DNMs in the second generation were post-zygotic, and present in both somatic and germ cells; these gonosomal mutations occurred at equivalent frequencies on both parental haplotypes. Our results demonstrate that rates of germline mutation accumulation vary among families with similar ancestry, and confirm that post-zygotic mosaicism is a substantial source of human DNM.

The range for maternal age ends in the late 30s, thus, it's possible that maternal age has an exponentially increasing risk of DNM proceeding the late 30s.

Graph

Risate · 2023-02-22T14:28:14+00:00

wait so.... as a teenager, older parents give you more miutations? Ur not born as a teen tho... am i missing something?

CornellWest · 2023-02-23T18:57:06+00:00

How do they attribute DNMs specifically to mother vs father? If it's a mutation then doesn't that mean it doesn't match either parent? I don't get it. I'm not challenging the paper just hoping someone can ELI5 me

justLernin · 2023-03-13T14:54:35+00:00

So... ideally have kids as young as possible?

Maybe encourage your kids to have kids really young, and help them raise them?

Professional-Cash490 · 2023-03-29T20:53:06+00:00

I think humanity may owe quite a bit to some of these mutations. One really good mutation could be worth a lot of autists.

Title	Starting in the late teens, the parental age of both sexes positively correlates with de novo mutations in offspring, with paternal age providing a stronger correlation.
Author	RSDevotion1
Upvotes	46
Comments	18
Date	February 22, 2023 2:50 AM UTC (3 years ago)
Subreddit	Posted in /r/BlackPillScience
Original Link	https://old.reddit.com/r/BlackPillScience/comments/118mx7w/starting_in_the_late_teens_the_parental_age_of/
Archive Link	https://theredarchive.com/r/BlackPillScience/starting-in-the-late-teens-the-parental-age-of.1153804 https://theredarchive.com/post/1153804

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