http://www.columbia.edu/~rmk7/HC/HC_Readings/Argyle.pdf
Excerpts:
There is more Eye Contact (EC) when the subject is listening than when he is speaking, typically with a ratio of 2 1/2 or 3:1
People look up at the end of their speeches and of phrases within them, and look away at the start of long uterances.
There is more EC when less personal topics are discussed, and when the material is cognitively straightforward. There is less during unfluent and heistating passages.
There is more eye contact if people like eachother, are cooperating rather than competing. There is less eC if there is tension in the relationship or if one has recently deceived the other.
Pairs of people develop an "Intimacy Equilibrium" with eachother. Intimatcy is a combination of: Eye-contact, physical proximity, intimacy of topic, amount of smiling, etc. If one of the components of intimacy is changed, one or more of the other elements will shift in direction to maintain the equilibrium
Subjects in groups... were least likely to speak to those nearest to them and most likely to address those two or three places away.
TL;DR: There are a ton of good info how people naturally calibrate based on comfort, intimacy etc.
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