This could be an everyone problem honestly, but seriously when I talk to women they literally don't care what I'm saying unless it directly relates to them or their own interests.

Ask them what their favorite book is they will talk your ear off. You try and tell them about your favorite book and they don't know it or don't like it "cool".

The what do you do for work question always cracks me up. Because it's always the same response "Oh that's cool.'

You have a hobby you're really into that they know nothing about. "That's cool."

I seriously feel like if I'm not drudging up topics the girl is actively interested in I get almost zero engagement.

This isn't just a one off experience. This has literally be a problem I'm starting to come to terms with that has happened my entire life. Almost every single interaction is like this. I say this as someone who has casually dated, been in long term relationships. This isn't just "The girl isn't into you."

I'm recently left with the feeling why am I never talking to you in the first place.

Women could be experiencing the same thing from men as well honestly (I wouldn't know).

TL;DR even if the person talking to you likes you they don't give a flying f what you like if they are not into it.