Women hate the manosphere because the manosphere teaches men to protect themselves from women, which makes it harder for women to exploit us

The manosphere, generally, teaches men to:

• Avoid marriage, because men lose a lot of leverage against their partners when they do, men generally have more to lose in a divorce, and women initiate most divorces.
• Avoid investing too much in women, to avoid making them view you as a provider, financially objectify you and essentially treat you like an ATM. And to filter out those who would.
• Prioritize your own interests(career, sexual satisfaction, etc.) over your partner's interests when they conflict.

Of course, the "manosphere" is not a monolith, but these are some of the popular common themes among different groups that get put in this category, like MRA's, MGTOW, and TRP(well, at least in the past).

All of these directly hurt women's ability to lock men down, to leech off of us, to hold us hostage in sexless relationships and marriages, etc. That's why they're so vocally hostile to the manosphere.

Of course they won't say that outright, they will dress up their criticism differently, like accusing the manosphere of "misogyny" and "stereotyping/demonizing women".

But this accusation is laughable considering how women habitually say similar things about men to each other. Women habitually tell each other to be suspicious of men and our behavior warning each other about men being cheap, men being deceptive, men being physically or sexually aggressive, etc.

So the manosphere isn't doing anything that most women aren't already doing. If individuals and groups in the manosphere are "misogynistic" for saying these things, generalizing women, and advising men to treat women with some suspicion, then most women are misandrist.